Alternative sources of beta cells for cell therapy of diabetes
نویسندگان
چکیده
منابع مشابه
Cell-based therapy of diabetes: what are the new sources of beta cells?
Diabetes affects 246 million people around the world. To date, no definitive cure has been discovered. Recent clinical trials have shed light on the possibility of successfully transplanting adult pancreatic islets into type 1 diabetic recipients. However, despite encouraging efforts to improve such protocols, the poor availability of pancreatic islets remains a limiting parameter for these tra...
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Adult hepatocyte transplantation is limited by scarce availability of suitable donor liver tissue for hepatocyte isolation. New cell-based therapies are being developed to supplement whole-organ liver transplantation, to reduce the waiting-list mortality rate, and to obtain more sustained and significant metabolic correction. Fetal livers and unsuitable neonatal livers for organ transplantation...
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Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the efficiency and safety of this procedure. Beta cells can be transdifferentiated from precursors or a...
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ژورنال
عنوان ژورنال: European Journal of Clinical Investigation
سال: 2003
ISSN: 0014-2972
DOI: 10.1046/j.1365-2362.2003.01190.x